- Product Name: HEK293 human ACE2
- Catalog No.: C2021-001
- Tube Label: HEK293 pcDNA_IN-WT-ACE2
Target: Angiotensin-converting enzyme 2 (human ACE2)
- Parental Cell Line: HEK293
- Organism: H. sapiens
Tissue: embryonal kidney
- Morphology: adherent fibroblastoid cells growing as monolayer
- Mycoplasma Test: negative (provided by Eurofins Genomics)
- Biosafety Level: 1
- Culture properties: adherent
The human Angiotensin-Converting Enzyme 2 (hACE2) is a type I transmembrane metallocarboxy-peptidase with homology to ACE, an regulator in the Renin-Angiotensin system (RAS) and long-known as a target for the treatment of hypertension.
hACE2 is expressed at the surface of cells of the human lungs, arteries, kidneys, heart and intestine – all tissues shown to harbor SARS-CoV. The function of ACE-2 is known as controlling blood pressure. This is accomplished by the hydrolysis of a small peptide hormone called Angiotensin II into angiotensin 1-7 by ACE and other endopeptidases. Angiotensin 1-7 acts in a vasoconstricting manner and is therefore involved in diabetes, hypertension and cardiac function in general.
Recently it became known, that the new Coronavirus SARS-CoV-2 uses ACE2 as the entry point into alveolar cells of the lungs, where it replicates and causes the Coronavirus disease (COVID-19).