SARS-CoV-2 S1 (RBD) Beta, B.1.351 (South Africa), GFP/His-Tag

€470.00

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SKU: P2020-042 trenzyme

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Recombinant protein of the receptor binding domain (RBD), Mutant (K417N-E484K-N501Y) of SARS-CoV-2 (COVID-2019) Spike S1 from Wuhan pneumonia virus with N-terminal His-Tag and C-terminal GFP. The mutations K417N-E484K-N501Y are characteristic for the fast spreading SARS-CoV-2 virus variants B.1.351 emerged in South Africa. These mutations are affecting the receptor binding domain (RBD) of the spike protein, which the virus uses to bind to human cells receptors and enter them. Due to the mutations, the virus is allowed to bind with higher affinity to human ACE2 receptor which results in increased transmissibility of the SARS-CoV-2 virus.

Overview

  • Product Name: SARS-CoV-2 S1 (RBD) (K417N, E484K, N501Y), GFP/His-Tag
  • Catalog No.: P2020-042
  • RefSeq Links: NC_045512.2; MN908947.3; YP_009724390.1; QHD43416.1; GeneID: 43740568; UniProt: P0DTC2
  • Synonyms: SARS-CoV-2; coronavirus; SARS-CoV-2 spike RBD; SARS-CoV-2 spike protein; 2019-nCoV; COVID-2019; COVID-19; RBD (N501Y); 501.V2; VUI-202012/01; B.1.1.7; B117; U.K. Variant; U.K. lineage; B.1.351; B1351; South Africa Variant; South African lineage; P.1; P1, Brazil Variant; Brazilian lineage; N501Y mutation of SARS-CoV-2 Spike