Alpha-1-antitrypsin

€490.00

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SKU: P2020-112 trenzyme

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Description

Recombinant Alpha-1-antitrypsin or also known as Alpha-1-proteinase inhibitor is an inhibitor of serine proteases (Serpin). Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator.

Overview

  • Product Name: Alpha-1-antitrypsin
  • Catalog No.: P2020-112
  • RefSeq Links: UniProt: P01009; NP_000286.3; NM_000295.4; PIR: A21853; GeneID: 5265
  • Synonyms: Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Serpin A1; A1AT Protein; Alfa1 antitrypsin; Alpha 1-antitrypsin; Alpha 1-Proteinase Inhibitor; Alpha 1-proteinase inhibitor (human); Alpha 1-proteinase inhibitor, human; Alpha-1 protease inhibitor; Alpha-1 proteinase inhibitor (human); Alpha-1-antiproteinase; Alpha-1-antitrypsin; Alpha-1-proteinase Inhibitor (human); Alpha-1-proteinase inhibitor human; Alpha-1-proteinase Inhibitor, Human; Alpha-1-proteinase inhibitor,human; Alpha1-proteinase Inhibitor; Alpha1-proteinase inhibitor (human); alpha1-proteinase inhibitor human; API

Sequence Information

  • Species: Homo sapiens, human
  • Tags: His-Tag, N-terminal
  • Sequence without tags (AA 25-418):
    EDPQGDAAQKTDTSHHDQDHPTFNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSIATA
    FAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNGLFL
    SEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELDRDT
    VFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKLSSWVL
    LMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSITGTYDLK
    SVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFLEAIPMSI
    PPEVKFNKPFVFLMIEQNTKSPLFMGKVVNPTQK

Product Information

  • Expression Host: human, HEK293
  • Formulation: 10 mM Tris, 200 mM NaCl, 1 mM EDTA, 1 mM ß-Mercaptoethanol; pH 8.0
  • Format: Liquid, stored and shipped at -80°C
  • Purity: > 95% as determined by SDS-PAGE

Background Information

Alpha-1-antitrypsin also known as Alpha-1 proteinase inhibitor is a serine protease inhibitor (Serpin). Its primary mechanism is inhibiting the action of the serine protease called elastase (also plasmin and thrombin) preventing the proteolysis of elastin tissues in alveolar lung structures. The reactive center loop (RCL) of alpha-1 proteinase inhibitor extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable.


SDS-PAGE/Coll. Coomassie

Histogram of marked lane in gel picture

SDS-PAGE of Alpha-1-antitrypsin Histogram (of marked lane in gel picture) Alpha-1-antitrypsin

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