Catalase
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SKU: P2020-127 trenzyme
Description
Catalase (KatA) from Helicobacter pylori is an enzyme used as biomarker for diagnostic of duodenal ulcer (DU).
Overview
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Product Name: Catalase
- Catalog No.: P2020-127
- RefSeq Links: UniProt: P77872; NP_207669.1; NC_000915.1; WP_000247370.1;, NC_018939.1; PDB: 1QWL; 2IQF
- Synonyms: KatA
Sequence Information
- Species: Helicobacter pylori
- Tags: GFP/His-Tag, C-terminal
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Sequence without tags (AA 1-505):
MVNKDVKQTTAFGAPVWDDNNVITAGPRGPVLLQSTWFLEKLAAFDRERIPERVVHAKGS
GAYGTFTVTKDITKYTKAKIFSKVGKKTECFFRFSTVAGERGSADAVRDPRGFAMKYYTE
EGNWDLVGNNTPVFFIRDAIKFPDFIHTQKRDPQTNLPNHDMVWDFWSNVPESLYQVTWV
MSDRGIPKSFRHMDGFGSHTFSLINAKGERFWVKFHFHTMQGVKHLTNEEAAEVRKYDPD
SNQRDLFNAIARGDFPKWKLSIQVMPEEDAKKYRFHPFDVTKIWYLQDYPLMEVGIVELN
KNPENYFAEVEQAAFSPANVVPGIGYSPDRMLQGRLFSYGDTHRYRLGVNYPQIPVNKPR
CPFHSSSRDGYMQNGYYGSLQNYTPSSLPGYKEDKSARDPKFNLAHIEKEFEVWNWDYRA
DDSDYYTQPGDYYRSLPADEKERLHDTIGESLAHVTHKEIVDKQLEHFKKADPKYAEGVK
KALEKHQKMMKDMHGKDMHHTKKKK
Product Information
- Expression Host: E. coli
- Formulation: PBS; pH 7.4.
- Format: Liquid, stored and shipped at -80°C
- Purity: > 75% as determined by SDS-PAGE
Background Information
Catalases are conserved and abundant enzymes found in all domains of life. They protect against oxidative stress and are highly expressed. In the gastric pathogen Helicobacter pylori, KatA levels are estimated to be up to 4-5% of the total protein content. The presence of the enzyme is ubiquitous, it could be detected in the cytoplasm, the periplasm and on the cell surface as well as being readily detected extracellularly. The enzyme is described to use heme as cofactor.
KatA is used as biomarker for duodenal ulcer (DU) and also for gastritic cancer (GC).
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SDS-PAGE/Coll. Coomassie |
Histogram of marked lane in gel picture |
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