Follistatin-related protein 3 (FSTL3) is a secreted glycoprotein involved in a myriad of intracellular signaling pathways by binding to activin-A and myostatin, members of the TGF-ß family, thereby suppressing their cellular activity. Thus, FSTL3 plays a role in health and disease. Analysis of FSTL3 expression can serve as diagnostic biomarker and in-depth knowledge of its actions on intracellular signaling pathways will lead to the development of new therapeutic approaches.
Product Name: Follistatin-related protein 3
- Catalog No.: P2020-128
- RefSeq Links: UniProt: O95633
- Synonyms: Follistatin-like protein 3; Follistatin-related gene protein; FSTL3; FSRP; Follistatin-Related Protein; Follistatin Like 3; Follistatin-Like 3 (Secreted Glycoprotein); Follistatin-Related Protein 3
- Species: Homo sapiens, human
- Tags: His-Tag, C-terminal
Sequence without tags (AA 27-263):
- Expression Host: human, HEK293
- Formulation: PBS; pH 7.4.
- Format: Liquid, stored and shipped at -80°C
- Purity: > 80% as determined by SDS-PAGE
Human follistatin-related protein 3 (FSTL3) is a secrected glycoprotein, which is structurally and functionally related to the activin-binding protein follistatin. It is expressed in various organs and tissues such as placenta, testis, heart and lung and plays an important role in a variety of cellular functions. By binding to activin-A and myostatin, both members of the TGF-ß family, FSTL3 antagonizes their cellular activity, thereby regulating physiological processes including cell differentiation and proliferation, metabolic pathways, inflammation and tumor development.
Histogram of marked lane in gel picture