SARS-CoV-2 S1 (RBD) Alpha, B.1.1.7 (U.K.)

€470.00

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SKU: P2020-035

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Recombinant protein of the receptor binding domain (RBD), Mutant (N501Y) of SARS-CoV-2 (COVID-2019) Spike S1 from Wuhan pneumonia virus with C-terminal His-Tag. The N501Y mutation is common for different of the currently observed fast spreading SARS-CoV-2 virus variants alpha, beta and gamma (B.1.1.7, B.1.351 and P1) that have emerged in recent months. The N501Y mutant is one of the most common and important mutations as it affects the receptor binding domain (RBD) of the spike protein, which the virus uses to bind to human cells receptors and enter them. Due to this mutation, the virus is allowed to bind with higher affinity to human ACE2 receptor which results in approximately 80% higher transmissibility of the SARS-CoV-2 virus alpha variant (B.1.1.7 lineage).

Overview

  • Product Name: SARS-CoV-2 (COVID-19) Spike S1 Protein (RBD, Mutant (N501Y))
  • Catalog No.: P2020-035
  • RefSeq Links: NC_045512.2; MN908947.3; YP_009724390.1; QHD43416.1; GeneID: 43740568; UniProt: P0DTC2
  • Synonyms: SARS-CoV-2; coronavirus; SARS-CoV-2 spike RBD; SARS-CoV-2 spike protein; 2019-nCoV; COVID-2019; COVID-19; RBD (N501Y); 501.V2; VUI-202012/01; B.1.1.7; B117; U.K. Variant; U.K. lineage; B.1.351; B1351; South Africa Variant; South African lineage; P.1; P1, Brazil Variant; Brazilian lineage; N501Y mutation of SARS-CoV-2 Spike